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Since the quality of the solutions for these optimization problems is critical for the performance of WDM networks, it is extremely important to have ef cient algorithms with good guaranteed performance for those problems However, it is challenging to develop such algorithms in most cases For example, the RWA problem is NP-hard for even very simple networks like rings and trees [9,19] Inapproximability results are known for the RWA problem in networks with more complex topologies when the routing paths are given [32] Similar hardness results are known for the other optimization problems as well For those problems on simple networks like rings and trees, many ef cient algorithms with good guaranteed performance have been known But for the problems on more complex networks, no effective approach has been developed and the existing algorithms are based on the integer linear programming or ad hoc heuristics.

5 Induction of stress proteins Stress proteins is a general term used to describe any protein for which there is an increased synthesis in response to a stressor In addition to heat-shock proteins (HSPs), this term also includes metallothionein, heme oxygenase and acute phase proteins Only HSPs will be considered here..

j =0

The performance of those algorithms are not guaranteed Readers may refer to other works on the subject [1,32,38,40,41] for more details on the minimization problems on complex networks In this chapter,.

Current services have a strong historical and socio-political legacy. Understanding the development of services requires an appreciation of these factors. Medieval historians debate the rst documentation of women suffering with illnesses which appear to t modern day criteria for anorexia nervosa and discuss early aetiological theories. It was in 1873 that the physician Sir William Gull nally named the disorder while working at Guy s Hospital, London (Gull, 1873). Although psychosocial factors were recognised in the aetiology of the condition it was general physicians who took the lead in the management of anorexia nervosa during the nineteenth century and the rst half of the twentieth (see Figure 20.1). During the latter part of the twentieth century we saw a gradual shift in the management of anorexia nervosa from physicians to psychiatrists in most European countries,

to the estimated distribution, which is then renormalized (cf. the notion of Laplace correction mentioned in Section 5.2). For a numeric attribute Aj the standard maximum likelihood estimation functions for the parameters of a normal distribution may be used, namely j (ci ) = 1 N(C = ci )

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Figure 2.9 Approximation scales for feature. Total depending on the categories CI, C II, and CIII (from left to right). (From [3].)

Ptosis Eye movement abnormality which doesn't necessarily match gaze palsy, internuclear ophthalmoplegia, or cranial nerve palsy Variability Fatiguability Normal pupils

withal for enhanced movement in life, whereas respecting autonomy requires that the person s chosen direction should be respected, whether or not the health worker approves of it. This idea is bedevilled with controversy. Many of the really hard cases in medical ethics hinge upon whether or not respect autonomy should be invoked. Some of these controversies can be settled with intelligent use of the grid, but there are no binding guidelines about how far personal (or group) autonomy ought to be respected. A strong (though not immutable) reason not to respect autonomy arises when the autonomous decision will harm other people. Beyond this, the issues must be resolved by personal judgement and comprehensive and appropriate moral reasoning.